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Creators/Authors contains: "Yang, Chun-tao"

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  1. ; ; ; ; (, Organic Letters)
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  2. ; ; ; ; (, British Journal of Pharmacology)
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  3. ; ; ; ; ; (, Angewandte Chemie International Edition)
    Abstract Thionitrous acid (HSNO), the smallest S‐nitrosothiol, is emerging as a potential key intermediate in cellular redox regulation linking two signaling molecules H2S and NO. However, the chemical biology of HSNO remains poorly understood. A major hurdle is the lack of methods for selective detection of HSNO in biological systems. Herein, we report the rational design, synthesis, and evaluation of the first fluorescent probe TAP‐1 for HSNO detection. TAP‐1 showed high selectivity and sensitivity to HSNO in aqueous media and cells, providing a useful tool for understanding the functions of HSNO in biology. 
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